abstract：:Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...

journal_title：Human pathology

authors： Annan AC,Stevens KA,Osunkoya AO

更新日期：2017-07-01 00:00:00

abstract：:T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

journal_title：Human pathology

authors： Hu Z,Li S,Medeiros LJ,Sun T

更新日期：2017-07-01 00:00:00

abstract：:Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated pro...

journal_title：Human pathology

authors： Jang S,Hong M,Shin MK,Kim BC,Shin HS,Yu E,Hong SM,Kim J,Chun SM,Kim TI,Choi KC,Ko YW,Kim JW

更新日期：2017-07-01 00:00:00

abstract：:There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...

journal_title：Human pathology

authors： Singh K,Wang Y,Marketkar S,Kalife ET,Steinhoff MM

更新日期：2017-07-01 00:00:00

abstract：:CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...

journal_title：Human pathology

authors： Shah SS,Wu TT,Torbenson MS,Chandan VS

更新日期：2017-06-01 00:00:00

abstract：:Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...

journal_title：Human pathology

authors： Xerri L,Huet S,Venstrom JM,Szafer-Glusman E,Fabiani B,Canioni D,Chassagne-Clément C,Dartigues-Cuilléres P,Charlotte F,Laurent C,Gelas-Dore B,Bolen CR,Punnoose E,Bouabdallah R,Brice P,Morschhauser F,Cartron G,Olive D,S

更新日期：2017-06-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untransl...

journal_title：Human pathology

authors： Menke JR,Vasmatzis G,Murphy S,Yang L,Menke DM,Tun HW,King RL,Smoley SA,Ketterling RP,Sukov WR

更新日期：2017-06-01 00:00:00

abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...

journal_title：Human pathology

authors： Wei Q,Zhou H,Zhong L,Shi L,Liu J,Yang Q,Zhao T

更新日期：2017-06-01 00:00:00

abstract：:Recent studies demonstrated that protease-activated receptor-2 (PAR-2) correlates with tumor progression in various tissues. On the other hand, oxidative stress arising from endometriosis has been considered a cause of carcinogenesis in ovarian clear cell carcinoma (OCCC). We previously demonstrated that oxidative str...

journal_title：Human pathology

authors： Aman M,Ohishi Y,Imamura H,Shinozaki T,Yasutake N,Kato K,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...

journal_title：Human pathology

authors： Wang H,Kohashi K,Yoshizumi T,Okumura Y,Tanaka Y,Shimokawa M,Iwasaki T,Aishima S,Maehara Y,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...

journal_title：Human pathology

authors： Krencz I,Sebestyén A,Fábián K,Márk Á,Moldvay J,Khoor A,Kopper L,Pápay J

更新日期：2017-04-01 00:00:00

abstract：:We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces wer...

journal_title：Human pathology

authors： Michal M,Skálová A,Kazakov DV,Pecková K,Heidenreich F,Grossmann P,Michal M

更新日期：2017-03-01 00:00:00

abstract：:Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted t...

journal_title：Human pathology

authors： Silva Amancio AM,Cunha IW,Neves JI,Quetz JD,Carraro DM,Rocha RM,Zequi SC,Cubilla AL,da Fonseca FP,Lopes A,Cunha MD,Lima MV,Vassallo J,Guimarães GC,Soares FA

更新日期：2017-03-01 00:00:00

abstract：:Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...

journal_title：Human pathology

authors： Chu S,Wen Q,Qing Z,Luo J,Wang W,Chen L,Feng J,Xu L,Zang H,Fan S

更新日期：2017-03-01 00:00:00

abstract：:Metanephric stromal tumors (MSTs) are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors, along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of ...

journal_title：Human pathology

authors： Marsden L,Jennings LJ,Gadd S,Yu M,Perlman EJ,Cajaiba MM

更新日期：2017-02-01 00:00:00

abstract：:Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved...

journal_title：Human pathology

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-02-01 00:00:00

abstract：:The authors present 11 cases of plexiform neurofibroma (PN) that featured a very characteristic type of cell appearing as multivacuolated mucin-filled cells (MMFC). The 11 cases were obtained after reviewing 109 cases of PN. Six out of 10 patients showed clinical features of neurofibromatosis type 1. The size of PN ra...

journal_title：Human pathology

authors： Michal M,Kazakov DV,Hadravský L,Michalová K,Rychlý B,Michal M

更新日期：2017-02-01 00:00:00

abstract：:We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...

journal_title：Human pathology

authors： Wobker SE,Zhong M,Epstein JI

更新日期：2017-01-01 00:00:00

abstract：:Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papillomavirus infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluat...

journal_title：Human pathology

authors： Velez-Perez A,Wang XI,Li M,Zhang S

更新日期：2017-01-01 00:00:00

abstract：:Pulmonary nodular lymphoid hyperplasia (PNLH) may show heavy lymphoplasmacytic infiltrates with increased immunoglobulin G4 (IgG4)-positive plasma cells as in IgG4-related disease (IgG4-RD). However, it is unclear whether PNLH could be a manifestation of IgG4-RD. A recent study reported the presence of Epstein-Barr vi...

journal_title：Human pathology

authors： Bois MC,Sekiguchi H,Ryu JH,Yi ES

更新日期：2017-01-01 00:00:00

abstract：:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...

journal_title：Human pathology

authors： Koeneman MM,van Lint FHM,van Kuijk SMJ,Smits LJM,Kooreman LFS,Kruitwagen RFPM,Kruse AJ

更新日期：2017-01-01 00:00:00

abstract：:Follicular lymphoma with MYC and BCL2 translocations, so-called double-hit follicular lymphoma (DH-FL), is rare. Here, we report the clinicopathological features of 7 cases of DH-FL. All neoplasms had a follicular pattern (1 partially diffuse). Five cases were predominantly low grade, 4 of which had focal (≤20%) grade...

journal_title：Human pathology

authors： Miao Y,Hu S,Lu X,Li S,Wang W,Medeiros LJ,Lin P

更新日期：2016-12-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...

journal_title：Human pathology

authors： Ni H,Zhang XP,Wang XT,Xia QY,Lv JH,Wang X,Shi SS,Li R,Zhou XJ,Rao Q

更新日期：2016-12-01 00:00:00

abstract：:Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value ...

journal_title：Human pathology

authors： Li X,Xiao Y,Fan S,Xiao M,Wang X,Zhu X,Chen X,Li C,Zong G,Zhou G,Wan C

更新日期：2016-11-01 00:00:00

abstract：:Alterations in the Notch signaling pathway play a role in colorectal cancer (CRC). Hes1, a Notch-induced transcription factor, has recently been reported to show decreased expression by immunohistochemistry in sessile serrated adenomas. Variable staining patterns have been reported in tubular adenomas, and existing da...

journal_title：Human pathology

authors： Ahadi M,Andrici J,Sioson L,Sheen A,Clarkson A,Gill AJ

更新日期：2016-11-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cell...

journal_title：Human pathology

authors： Boland JM,Folpe AL

更新日期：2016-11-01 00:00:00

abstract：:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...

journal_title：Human pathology

authors： Wang W,Zou B,Zhu H,Bao Y

更新日期：2016-10-01 00:00:00

abstract：:Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

journal_title：Human pathology

authors： Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

更新日期：2016-10-01 00:00:00

abstract：:Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series h...

journal_title：Human pathology

authors： Villacorta J,Diaz-Crespo F,Acevedo M,Guerrero C,Campos-Martin Y,García-Díaz E,Mollejo M,Fernandez-Juarez G

更新日期：2016-10-01 00:00:00

abstract：:In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...

journal_title：Human pathology

authors： Clark JL,Lu D,Kalir T,Liu Y

更新日期：2016-09-01 00:00:00

abstract：:Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis in several malignancies but never in renal cancer. We aim to analyze the...

journal_title：Human pathology

authors： López JI,Errarte P,Erramuzpe A,Guarch R,Cortés JM,Angulo JC,Pulido R,Irazusta J,Llarena R,Larrinaga G

更新日期：2016-08-01 00:00:00

abstract：:Five hundred eighty renal biopsies from a pool of 27850 archived cases were identified in which a myoglobin stain was performed because of atypical casts. Two hundred and thirty-eight (41%) of these biopsies were found to be positive for myoglobin casts. The morphology of the myoglobin casts ranged from light, almost ...

journal_title：Human pathology

authors： Liapis H,Boils C,Hennigar R,Silva F

更新日期：2016-08-01 00:00:00

abstract：:Polymer substances are commonly applied as surface coatings on endovascular catheters and vascular devices. Adverse effects related to their use have been reported, although the overall clinical significance and appropriate methods of detection of these complications have been unclear. In this analysis, we systematica...

journal_title：Human pathology

authors： Mehta RI,Mehta RI

更新日期：2016-07-01 00:00:00

abstract：:Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...

journal_title：Human pathology

authors： Kadokura A,Frydenlund N,Leone DA,Yang S,Hoang MP,Deng A,Hernandez-Perez M,Biswas A,Singh R,Yaar R,Mahalingam M

更新日期：2016-07-01 00:00:00

abstract：:Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...

journal_title：Human pathology

authors： Zhang JF,Chen Y,Lin GS,Zhang JD,Tang WL,Huang JH,Chen JS,Wang XF,Lin ZX

更新日期：2016-06-01 00:00:00

abstract：:Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...

journal_title：Human pathology

authors： He D,Manzoni A,Florentin D,Fisher W,Ding Y,Lee M,Ayala G

更新日期：2016-06-01 00:00:00

abstract：:The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...

journal_title：Human pathology

authors： Yeh MM,Belt P,Brunt EM,Kowdley KV,Wilson LA,Ferrell L,Nonalcoholic Steatohepatitis Clinical Research Network.

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic ...

journal_title：Human pathology

authors： Bauman TM,Vezina CM,Ricke EA,Halberg RB,Huang W,Peterson RE,Ricke WA

更新日期：2016-05-01 00:00:00

abstract：:It remains unclear why Barrett esophagus (BE)-associated adenocarcinoma (EAC) frequently occurs in the 0 to 3 o'clock area of the BE. The aims of this study were to clarify the localization of specialized intestinal metaplasia (SIM) as a precancerous lesion and of molecular alterations among different locations using ...

journal_title：Human pathology

authors： Fukui S,Watari J,Tomita T,Yamasaki T,Okugawa T,Kondo T,Kono T,Tozawa K,Ikehara H,Ohda Y,Oshima T,Fukui H,Das KM,Miwa H

更新日期：2016-05-01 00:00:00

abstract：:The SHH signaling pathway is critical for gastrointestinal development and organic patterning, and dysregulation of SHH pathway molecules has been detected in multiple gastrointestinal neoplasms. This study investigated the role of the SHH signaling pathway in PJS. Expression of SHH, PTCH, and GLI1 was examined by rea...

journal_title：Human pathology

authors： Xu X,Su J,Li R,Wang Y,Zeng D,Wu B

更新日期：2016-04-01 00:00:00